Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
Summary: Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease.Kinase target recognition at the active site is in part determined by a few amino acids around the phosphoacceptor residue.However, relatively little is known about how most preferences are encoded in the kinase sequence or Hand Cream how these pr